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Lonza expands manufacturing collaboration for Altimmune COVID-19 vaccine candidate

March 16/2021

MOSCOW (MRC) -- Lonza says it has expanded its manufacturing collaboration with Altimmune (Gaithersburg, Maryland), a clinical-stage biopharmaceutical company, for Altimmune’s single-dose intranasal COVID-19 vaccine candidate, AdCOVID, said Chemweek.

Lonza will commission a dedicated manufacturing suite for clinical and commercial production of AdCOVID, at its facility near Houston, Texas, under the terms of the agreement. “Manufacturing capacity for COVID-19 vaccines has been severely constrained, and this limitation has presented considerable challenges for vaccine developers. By expanding our Lonza collaboration and commissioning our own dedicated manufacturing suite, we are building extra capacity and redundancy into our manufacturing to support potential late-stage clinical trials with AdCOVID and potential future commercial supply,” says Vyjayanthi Krishnan, vice president/product development at Altimmune.

AdCOVID is administered via nasal spray and preclinical studies have shown that it activates systemic immunity—neutralizing antibodies and T cell responses—and mucosal immunity in the respiratory tract, Lonza says. Activation of mucosal immunity may prevent infection and transmission of SARS-CoV-2 virus, responsible for the COVID-19 pandemic, the company says.

“We recently commenced our AdCOVID phase 1 clinical trial and anticipate having a data readout in the second quarter of 2021. If the clinical data from our phase 1 trial and subsequent clinical trials validate our preclinical observations and AdCOVID is successfully commercialized, we believe that it could become an important new option for vaccination against COVID-19, offering the simplicity of nasal administration, potential ease of deployment and storage, and the potential to block viral transmission,” says Vipin Garg, president and CEO at Altimmune.

We remind that in 2012, Lonza set up a task force to look at new supply routes and vendors to feed its cracker in Visp, Switzerland, following the shutdown of Petroplus’ refinery at Cressier in January, 2012. Lonza’s cracker has an ethylene capacity of 25,000 tonnes/year.

Ethylene and propylene are feedstocks for producing PE and polypropylene (PP).

According to MRC's ScanPlast report, Russia's estimated PE consumption totalled 241,030 tonnes in January 2021 versus 217,890 tonnes a year earlier. Only shipments of low density polyethylene (LDPE) and high density polyethylene (HDPE) increased. At the same time, PP shipments to the Russian market reached 141,870 tonnes in January 2021 versus 123,520 tonnes a year earlier. Supply of homopolymer PP and PP block copolymers increased.

 


mrcplast.com
Author:Anna Larionova
Tags:PP, PE, ethylene, propylene, neftegaz, petrochemistry.
Category:General News
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